Loudon Wainwright III's "New Street People"

I'm currently listening to Loudon Wainwright III's Social Studies.  I found a reference to Shakespeare's Hamlet in "New Street People."  Wainwright's line is "a thousand toxic, natural shocks," which adds only one word (toxic) to a sentence from Hamlet's famous "to be or not to be" soliloquy:  "To die--to sleep-- / No more; and by a sleep to say we end / The heartache, and the thousand natural shocks / That flesh is heir to" (III.i.68-71).

However, I'm not exactly sure what Wainwright is trying to say with that Hamlet quote.