A few days ago, I listened to a compilation album of Ritchie Valens. I really like his "Now You're Gone," so I decided to learn how to play it. I think I figured it out one other time (or at least figured out most of it) because I sort of remembered it.
In any case, I learned some cool things about it. First, it starts off with a key change... sort of. It starts in C# minor (for three chords) but then changes key to E major. They contain all the same notes though, so I'm not sure if it's technically a key change.
Second, while it is mostly a three-chord song, it has E major 6ths, which I don't think is something that's all too common in 1950s songs.
EDIT: I'd been playing this with a capo on the 2nd fret, so all of the chords I said are relative to the capo. It actually starts in D# minor and changes key to F# major. And it contains an F# major 6th. So even aside from the sudden key change and major 6th chords, there's something else distinctive about it - it's in an unusual key compared to most 1950s songs.